Graft-versus-host disease GVHD is a potentially serious complication of allogeneic stem cell transplantation and reduced-intensity allogeneic stem cell transplantation. During allogeneic stem cell transplantation, a patient receives stem cells from a donor or donated umbilical cord blood. Graft-versus-host disease can be mild, moderate or severe. In some cases, it can be life-threatening. There is no standard regimen for the prevention of GVHD, and different combinations of medications are given at different institutions. Some common medications that are given to prevent GVHD include. There are two main categories of GVHD: acute graft-versus-host disease and chronic graft-versus-host disease. Each type affects different organs and tissues and has different signs and symptoms. Patients may develop one type, both types, or neither type.
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